The Aging Intervention Foundation
(AIF) is
a 501(c)(3) non-profit organization created to develop new therapies
to control and reverse the causes of aging, as well as treat
and prevent the diseases of aging.
The goal is to eventually control
the processes of aging, reverse their effects, and stay
younger longer – and ultimately create indefinite youthful,
happy and productive
lifespan using innovative
scientific methods that are under development today in biotech companies and research
labs around the world.
The foundation also offers education on what we can do now to
stay younger, live longer and be happier
while new therapies are being developed.
If you are interested in supporting the foundation or
would like more information, click here to contact us
Some of the causes of aging recognized by aging
intervention scientists for which we will find solutions:
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Oxidation, glycation, cross-linking,
and other chemical modifications acting to impair the molecular
functioning of multiple vital components in the body. Those affected include DNA, membranes,
the extracellular matrix (ECM), enzymes, and structural proteins |
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Debris and disorganization – both intracellular
(inside the cell) and extracellular (outside the cell) |
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Alteration in chemical equilibrium of cells (change in redox potential poise) -- results in a decreased ability to
manage highly reactive and damaging molecules. This causes alterations in gene expression,
enzyme activity, and signaling pathways Cell atrophy and loss |
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Cell atrophy and loss |
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Nuclear mutations – in nucleus, including DNA |
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Decrease in repair and recycling effectiveness |
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Mutant mitochondria (mitochondria are the “energy factories” within
the cells that also control cellular processes)
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Harmful cells that are resistant to death -- visceral fat cells, supernumerary cells
(toxic cells that accumulate in the cartilage in our joints and elsewhere) and dysfunctional
immune cells)
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Conditions we will control:
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Stop DNA Breakage -- Broken DNA improperly codes for functions
in your body resulting in poor health and aging |
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Prevent Protein Unfolding -- Proteins can take the form of elegant
molecules in the body that compose the body, as well as manage its functions. They
can be extremely complex, and are formed in with folds in specific ways. Often they
become unfolded, so they cannot do their jobs properly. We want to find ways to
keep them in their correct shape and functioning properly. |
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Prevent cells from aging, and prevent faulty replication -- Activation
of the cell repair process will be accomplished primarily through adult stem cells.
AIF favors the use of adult stem cells. Although stem cell research is being conducted
in a great many labs thruout the world, AIF will monitor this and fund development
work in areas being overlooked, with emphasis on providing software systems to facilitate
information sharing and collaboration among researchers |
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Prevent and Cure Diseases Caused By Specific Genes |
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Prevent Telomere Shortening -- Telomeres are the ends of DNA sections
that shorten each time the cell replicates. When the telomere length falls below
a certain threshold the cell no longer can divide |
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Preserve and repair mitochondria |
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Enable lysosomes (cell components) to eliminate harmful substances that accumulate
with age |
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Remove harmful amyloid from the brain, as well as pancreas,
heart and other organs |
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Control Oxidative Stress (free radical damage) Oxidative
stress is caused by highly reactive molecules (“free radicals”) that are created
in the energy factories within cells that go on to wreak havoc and damage cells
and organs. It is involved in many diseases, such as atherosclerosis, Parkinson's
disease and Alzheimer's disease. Therapeutics to mimic the positive effects of restricting
caloric intake, among others, can help prevent these conditions |
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Prevent and Reverse
the Glycation of Molecules in the Body Prevent proteins and other molecules from
“crosslinking”, or sticking together and no longer work properly |
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Stimulate The
Reversal Of Cholesterol Transport -- Pick up cholesterol from arteries and dispose
of it |
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Repair and Restore Vascular Endothelial Function -- Restore clogged and damaged vessels |
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Stimulate Heat Shock Proteins -- Heat shock proteins are a class of proteins
that protect other proteins and prevent them from unfolding under conditions of
stress, such as heat |
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Reverse the wear and tear that accumulates over time |
If you are interested in supporting the foundation or
would like more information, click here to contact us
Some methods to accomplish the above:
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Conventional pharmaceuticals |
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Stem Cell Therapies -- Stem cells differentiate into a wide
range of specialized cell types will be used to repair damaged tissues. Recent evidence
that certain cells from adults may hold much of the curative potential previously
believed unique to embryonic stem cells |
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Genetic engineering -- Modifying and enhancing DNA |
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Drugs that mimic caloric restriction -- So far restricting caloric
intake is the only method shown to increase lifespan in animals. A calorimemetic
would mimic this effect without restricting the diet
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Nutraceuticals -- Foods with medicinal properties
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Eventually, advanced methods like nanotechnology and artificial intelligence
-- “Nanobots” are tiny molecular machines that will repair cells and DNA, and artificial
intelligence is the use of computers that mimic the thought processes of humans
to solve complex biological (and other) problems
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How We’ll Do This
We’ll accomplish these goals by creating strategic partnerships
with world class organizations. The AIF will provide the vision, clearly defined
project plan and goals, specific technical expertise and money. All teams will be
racing together toward the common goal of greatly extending and improving our lifespan,
and the quality of our lives. Some representative organizations we will partner
with (note: all organizations will pass through a comprehensive due diligence process):
Supercentenarian Research Foundation
http://www.supercentenarian-research-foundation.org/
The premise behind the SRF is: If you want to know how to do
something, find out from someone who has already done it. The mission of the SRF
is to promote scientific research into the causes of aging initially by funding
investigations into its effects in supercentenarians (people who have attained the
age of 110 years or greater). The knowledge gained can help develop methods to improve
health and longevity.
Some of the research hypotheses the SRF is planning in order to provide key information
in the development of new aging interventions include:
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Supercentenarians live longer in part because they maintain immune competence longer |
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They live longer in part because they have an ideal or more ideal balance of blood
lipids (HDL, LDL, triglycerides – and subcategories of these) than others |
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Supercentenarians either tolerate lower levels of the hormone IGF-1, or between
IGF-1 levels and suppression of antioxidant defenses and DNA repair that underlie
the pro-aging effects of IGF-1 and insulin |
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They maintain their mitochondria better over time. Mitochondria are the cells’ power
plants |
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Their DNA repair mechanisms are more efficient |
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Supercentenarians live longer in part because they retain stem cell functionality
longer and better than do shorter-lived people |
Legendary Pharmaceuticals
http://www.LegendaryPharma.com/
Legendary Pharmaceuticals was established to develop pharmaceutical
drugs and gene therapies which repair and reverse accumulating molecular damage
to subcellular mitochondria, lysosomes, nuclei, and extracellular proteins in order
to prevent and treat serious late-onset diseases commonly associated with aging.
Ageless Animals (a.k.a. Centenarian Rockfish Project) http://www.AgelessAnimals.org
This project involves investigators at 14 universities who study
animals that live for up to hundreds of years but have not shown signs of aging.
Biogerontologists call this “negligible senescence”. Research efforts have included
histology, DNA microarray analysis, mitochondrial mutations, among others.
Kronos Science Laboratory
http://www.KronosLaboratory.com
Kronos Science Laboratory is a full-service provider of central
laboratory and contract research services to the pharmaceutical, biotechnology,
and clinical research industries. KSL has a state-of-the-art laboratory using a
wide variety of analytical technology and equipment to meet the testing needs of
clients.
MaxLife Foundation
http://www.maxlife.org
The MaxLife Foundation will be supporting both public and private
research on the aging process and will foster cooperation between academic and industry
labs. The Foundation is exploring every possible avenue to speed up research on
the disease processes associated with human aging and on the aging process itself.
We expect the tremendous economic, social, and emotional costs of human aging can
be greatly reduced through this effort.
Buck Institute
http://www.buckinstitute.org
The Buck Institute is the first independent research facility in the United States
to focus solely on aging and age-related conditions such as Alzheimer’s and Parkinson’s
disease, cancer, stroke, and arthritis. The Institute began its biomedical research
program in 1999. The National Institute on Aging designated the Buck Institute as
a "Nathan Shock Center of Excellence in the Biology of Age Research" in June 2005,
one of just five in the nation. The Buck Institute has the infrastructure to address
DNA Repair & Cancer, Mitochondrial Dysfunction & Aging, Molecular Genetics
of Lifespan Determination, Oxidative Stress & Aging: The Buck Institute research
runs through a peer-reviewed government and foundation grant process. (Issuing Requests
for Applications for grants would be needed in order to fit Buck’s model).
Other organizations we will work with are in “Aging Research and
Therapeutics Organizations” at:
http://www.JohnnyAdams.com/AgingResearchAndTherapeuticsOrganizations.pdf
If you are interested in supporting the foundation or
would like more information, click here to contact us
What We’ll Do First:
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Specify and award grants for projects identified as having highest priority |
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Ongoing project review and management |
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Continue to review the work of organizations involved in the development of, or
closely related to, aging therapeutics for which to award research grants. |
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AIF will be a central hub, repository and clearinghouse of scientific aging-intervention
information |
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AIF will facilitate communication and collaboration among people and organizations |
Some representative projects (note: all projects will pass through a comprehensive due diligence process):
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Project: |
Determine how to differentiate adult stem cells into different cell types. |
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Benefit: |
Rejuvenate tissues in all the major organs, including heart, lungs, kidneys, liver
and pancreas |
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Organization: |
L. Stephen Coles MD, PhD and researchers from three major universities |
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Timeframe: |
To be determined |
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Cost: |
Initial: Set up lab with proper equip to analyze stream of data $250 - 280K
Intermediate: Identify chemical language to activate stem cells. Determine how to
identify chemokines that will be tissue specific and turn a pluripotent (can be
grown to specialize in any bodily tissue) stem cell into the type of stem cell fated
to become an organ. $100-120k
Long term: Develop therapeutic or method. Cost to be determined |
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Create webcast to present Gerontology Research Group (GRG) meetings worldwide on
the web. Will be digitally stored so they can be viewed at any time. |
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Benefit: |
Will allow anyone in the world to “attend” GRG meetings and take advantage of the
information presented.
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Organization: |
Gerontology Research Group |
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Timeframe: |
Two Weeks |
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Cost: |
To be determined |
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Gather a large amount of biological data from supercentenarians and their relatives,
and analyze it to find what they have in common and why they live so long.
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Benefit: |
Allows for precision in the selection of aging therapeutics and methods to develop. |
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Organization: |
Supercentenarian Research Foundation |
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Timeframe: |
Nine months |
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Cost: |
$500 – 520K |
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Project: |
A prototype for this project has been completed: Enhance the prototype software
system to facilitate information sharing and collaboration among all research organizations
conducting projects funded by AIF.
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Benefit: |
Faster project results |
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Organization: |
AIF |
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Timeframe: |
Two months |
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Cost: |
$12 - 15K |
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Identify, isolate and amplify “pristine” adult stem cells. Currently, adult stem cells
in therapeutics or research are replicas of the patients’. That means, a 70 year old
patient will be treated with a 70 year olds stem cells. However, we all carry a
percentage of stem cells that have escaped damage during our lives or that
have had minimal damage or mutations. With a “pristine” stem cell line close to
100% of the stem cells will be in the best condition possible, possibly in the condition
the patient enjoyed as a child or teenager. Potential therapies could be to rejuvenate or
eventually replace hearts, livers, digestive systems, immune systems, skin, hair and more.
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Benefit: |
Less waste, more effective research and treatment and reduced cancer risk. |
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Organization: |
Pristine Stem Cells, Inc. |
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Timeframe: |
18-24 months |
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Cost: |
$2.5 – 3.0M |
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Project: |
Understand differences in gene expression that identify declining and toxic cells
in order to remove or kill them. |
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Benefit: |
Will lead to removal of visceral (around the organs) fat, improved immune response
and reduce or eliminate the risk of cancer. |
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Organization: |
To be named |
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Timeframe: |
3 – 5 yr. |
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Cost: |
Note: Three labs staffed by top scientists are currently pursuing this, and for
three separate aging conditions. Projects are currently being funded. AIF will add
$5-7M to this effort. |
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Introduce mitochondrial genes into the cell nucleus -- Thirteen of the approx. 1000
mitochondrial genes are located in the mitochondrion itself, and they are more exposed
to damage than mitochondrial genes that are within the cell nucleus. Introducing
them into the nucleus would protect them and allow them to continue to work. Three
of the 13 have been expressed in the nucleus in cell culture. This project would
help get some or all of the rest working in cell culture, the next steps being getting
them to work in a mouse, and eventually in humans. |
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Benefit: |
Protection from mutations, thereby allowing them to continue to the production of
energy, as well as play their parts in a range of other processes (cell signaling,
cellular differentiation, apoptosis, control of the cell cycle and cell growth). |
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Organization: |
We will fund several of at least a dozen laboratories are working on this problem
but with limited and uneven funding. |
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Timeframe: |
5 yr |
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Cost: |
AIF would contribute $3-5M to this effort. Note: More than any other project, this
would involve collaboration between researchers in labs in locations throughout
the world, this project would make good use of the software system to facilitate
information sharing and collaboration described in the second item above. |
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Project: |
Further refine development of a compound that will break protein crosslinks. Significant
work has been done (development of the compound ALT-711 and phase I and II clinical
trials) by pharmaceutical companies, but ALT-711 was abandoned because competitors
could easily copy. AIF would contribute to the development of others (such as the
new compound C36), and possibly extending the ALT-711 clinical trials. |
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Benefit: |
Will lead to restoration of elasticity and function of arteries and other parts
of the body. |
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Organization: |
To be named |
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Timeframe: |
9 mo. |
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Cost: |
$1-1.2M initially. We would then evaluate progress and fund accordingly. |
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Project: |
A software system created for SRF to manage supercentenarian demographic information.
Infrastructure will allow extension for management of biological data. Will allow
for data entry and management, and present information on supercentenarians and
their relatives. |
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Benefit: |
Scientists, researchers and lay people can answer questions, solve problems and
make sound decisions. |
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Organization: |
AIF in collaboration with Dynabyte Software Co. |
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Timeframe: |
Two months |
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Cost: |
$10 – 12K |
Background Summaries – Key People:
Johnny Adams -- CEO and Executive Director
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I'm uniquely qualified to manage aging intervention development
projects and to be your guide in slowing the process of aging. It took me years
of perseverance to separate the truth from all the hype about so-called anti-aging
“miracles”. I have been at the forefront of biotechnology and other medical technologies,
and studied and practiced health, fitness and aging intervention since 1979. I’m
experienced in biotechnical industry, bioinformatics, protein informatics, clinical
trials and programming, and knowledgeable in computer aided drug design and biomedical
software development. |
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USC MBA 1985, studied and practiced aging intervention / life extension for more
than 20 years. Experience in the business world and in life |
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Well connected with members of the medical and scientific community who are on the
leading edge of aging intervention development |
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Member, Organizing Committee: Anti-Aging Drug Discovery & Development Summit:
Exploring the Molecular Basis of Aging & Commercial Prospects for Therapeutic
Interventions 15-16 October 2002, Westin St. Francis, San Francisco |
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Authored Stay Younger, Be Happier, Live Longer Aging Intervention Manual
with Lord Lee-Benner, M.D. F.A.C.E. |
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Invested years in the study of aging and developing a personal system – it took
me years of perseverance to separate the truth from all the hype about so-called
anti-aging “miracles”. |
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Regularly attends conferences and workshops to learn state-of-the-art innovations
from world-class researchers. Most recent include monthly Los Angeles Gerongology
Research Group meetings, AGING The Disease - The Cure - The Implications (June 27,
2008), Understanding Aging: Biomedical and Bioengineering Approaches (June 28-29,
2008), UC Irvine Brain Imaging Center Sprague Symposium (Nov.
30 2007), the annual meeting of the Gerontological Society of America (San Francisco
CA, Oct. 17-19 2007), Life Extension Workshop (Los Angeles CA, Nov 17, 2007), Stem
Cell Symposium (Cal Tech, Pasadena CA, Nov 15, 2007), Tissue Sampling and Analysis
Workshop (Supercentenarian Research Foundation, Feb 23-25 2007) |
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Active with and volunteer for the Los Angeles Gerontology Research Group (www.grg.org).
Email list administrator, developed program to create centenarian tables for web
site |
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Active in Supercentenarian Research Foundation and Supercentenarian Research Working
Group to learn the secrets of successful aging from people who have done it |
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Worked in the biotech industry in San Diego, CA in the field of bioinformatics and
protein informatics. Studied drug design and molecular biology for the purpose of
applying knowledge to development in aging intervention. Met knowledgeable people
in a variety of specialties to team with in aging research projects |
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Helped bring the messages to the world by creating web sites for:
- Dr. Lee-Benner at www.theantiAgingdoctor.com and
- Centenarian Species and Rockfish Project --
Emerging Area of Aging Research: Long-lived Animals with
"Negligible Senescence" at www.AgelessAnimals.org
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Learning to speak Chinese in order to work with Chinese researchers (and to continue
brain stimulation) |
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Highly experienced in software development, computer programming and technology.
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Highly experienced in marketing and business
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Past volunteer for Olive Crest Homes for Abused Children, the United Way, Philant
non-profit health care organization, UCI Brain Imaging Center, and former Secy/Treas
for the Orange County Visual Basic User Group. Founder, "Johnny Adams & Friends
for Charity". Enjoys boating and fitness, exciting work and helping people, music,
family oriented. Featured in the Orange County Register (2/95). Information on recent
presentations to help disadvantaged kids is at www.JohnnyAdams.com/Volunteer/PressInfo.htm |
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Recently experienced the personal tragedy of helplessly witnessing the decline of
a loved one due to Alzheimers. This experience has hardened my resolve to develop
new ways to stay younger longer. |
L. Stephen Coles, MD, PhD -- Chief Science Officer
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Steve Coles is considered by many to be the
most knowledgeable person in aging
intervention research. Each month he presents the results of his extensive
research at the meeting of the Los Angeles Gerontology Research Group. |
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Co-Founder and Director of the Los Angeles Gerontology Research Group |
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Visiting Scholar, Dept. of Computer Science, UCLA School of Engineering |
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Former VP for Medical Education, The Kronos Group |
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Member of the MaxLife Foundation Scientific Advisory Board
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Member of the Organizing Committee, Director and Treasurer of the Supercentenarian
Research
Foundation |
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Author of over 115 scientific papers and holds two patents |
John C. Guerin, Research Project Director:
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John is a well respected member of the biogerontology community.
With a broad base of practical knowledge in aging intervention, he brings great
project management and accounting experience to the AIF. |
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Founder Centenarian Species and Rockfish Projuect -- Emerging Area of Aging Research:
Long-lived Animals with "Negligible Senescence" at www.AgelessAnimals.org |
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Featured in a chapter of Mavericks of Medicine: Exploring the Future of Medicine
with Andrew Weil, Jack Kevorkian, Bernie Siegel, Ray Kurzweil, and Others |
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Meetings and organizations John has made presentations to include: International
Association of Biomedical Gerontology 2003, AGE Conference (American Aging Association)
2001, American Aging Association 2000, Symposium on Organisms with Slow Aging 2000,
and the Los Angeles Gerontology Research Group 1999 |
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Member of the Scientific Advisory Board, Legendary Pharmaceuticals |
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Member of the Editorial Advisory Board for the Handbook of Animal Models for Aging
Academic Press/Elsevier |
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Project Management Professional certification, issued by Project Management Institute |
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Experience as senior accountant and business analyst. Led multi-department financial
project teams. Projects included Pharmacy Billing, Comparable Sales and Wage reporting,
Mail Routing and Warehouse Accruals |
If you are interested in supporting the foundation or
would like more information, click here to contact us
Scientific Board:
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L. Stephen Coles, MD, PhD -- Chief Scientist -- Background
summary is above
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John C. Guerin -- Background summary is above
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John Furber – Mr. Furber is an entrepreneur and scientist who has
been studying the biology of aging and regeneration for more than 20 years. He was
a principal in starting five companies during the 1980s and 90s. Currently, he is
running a biotechnology company, Legendary Pharmaceuticals, which is engaged in
the discovery of pharmaceutical drugs and gene therapies able to repair and reverse
accumulating molecular damage to subcellular mitochondria, lysosomes, nuclei, and
extracellular proteins in order to prevent and treat serious, late-onset diseases
commonly associated with aging.
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Michael Rose, PhD -- Dr. Rose has made significant contributions
to the field of aging research. He is a professor in the Department of Ecology and
Evolutionary, UC Irvine in Irvine CA USA. His main area of work has been the evolution
of aging.
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Aubrey de Grey, PhD – Dr. de Grey works to identify and promote
specific technological approaches to the reversal of the aspects of aging centered
around the detailed plan called Strategies for Engineered Negligible Senescence
(SENS).
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Executive Board:
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John Adams, Chief Executive Officer – Background described above |
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Christopher W. Cunningham, Chief Financial Officer – Mr. Cunningham
has a broad experience in finance, operating nonprofit organizations and businesses.
Former President, Orange County Wine Society. Mr. Cunningham holds a B.A. in Finance
from California State University Fullerton. |
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Michael M. McInnis, Secretary – Mr. McInnis has great experienced
in management and technology, and experience in legal matters. |
Frequently Asked Questions:
Q. Are you trying to create the Fountain of Youth?
A Yes, that’s basically it. And I half-jokingly add -- after that we’ll create the
well of wisdom and the geyser of eternal happiness – while helping to solve many
major problems of the world. I’m not just kidding. This is for people with a vision
of the betterment of future of humanity and all living things.
Q. Why should I be interested in this when I’m satisfied with a traditional life
which involves growing old naturally?
A. Well, I certainly won’t disagree with someone’s choice to grow old and die. But
personally I’d rather fight it.
Q. Isn’t all this “turning back the aging clock” awfully unrealistic?
A. That’s what was said about airplanes, computers, the electric light, and scores
of other innovations. The process of technological advancement is accelerating and
more and more scientific breakthroughs are being made each day. This is particularly
true in the biological sciences. We intend to harness this exponential growth to
accomplish our mission.
Q. Is my contribution tax deductible?
A. Yes. The Aging Intervention Foundation (also known as the Carl I. Bourhenne Medical
Research Foundation) is a 501(c)(3) tax exempt organization.
Q. Why should I put my money into this organization when there are hundreds of others
doing medical research?
A. The AIF is unlike any other organization. No other organization will help you
preserve your longevity the way the AIF will: 1) It is committed to your ongoing
health and longevity. It’s the only aging intervention organization taking a personal
approach to help you achieve added quality years, decades – and hopefully much much
more – to your life. 2) You’ll be in a unique position to take advantage of its
outcomes, and help forge the direction of the future of aging science. 3) Most other
organizations focus on one disease and on basic research (understanding how something
works). The AIF is taking the engineering approach of manipulating the underlying
causes of aging to intervene in the underlying causes of aging. These causes cause,
and predispose us to, numerous diseases and ill effects. Most importantly, intervening
in the processes of aging is about increasing the quality as well as quantity of
your life. 4) I created the AIF to cut thru the bureaucratic clutter many research
organizations are burdened with, and create therapeutics and other methods to keep
us younger longer as soon as possible.
Q. You’re not a doctor. How can someone who’s not a doctor lead this? A I have the
expertise of the best aging intervention physicians and researchers available. I
approach this from a lay perspective, with a results-orientation. I am probably
a lot like you, with a hunger for youthful, joyous life.
Q. Aren’t there tremendous opportunities for commercial development resulting from
aging research?
A. Yes, but my immediate concern is keeping us around long enough to capitalize
on them.
Q. Are you getting paid for this?
A. Right now I’m putting in a lot of my own time and foregoing significant earnings.
In the future I will be paid very decent compensation in line with the responsibility
of running the AIF.
Q. How do I know I can trust you?
A. I value health and longevity more than anything. The main reason I’m in this
is to take advantage of the aging intervention breakthroughs that will follow. I
have been doing this work since 1999. I value being a part of a unique, forward-thinking
group and pursuing this adventure. See my background summary above, and my book
at
www.JohnnyAdams.com/StayYoung.pdf
If you are interested in supporting the foundation or
would like more information, click here to contact us
Johnny Adams
CEO and Executive Director
Aging Intervention Foundation
3857 Birch Street, No. 182
Newport Beach, CA 92660
(949) 640-7528
www.AgingIntervention.org
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