A GING   I NTERVENTION
F OUNDATION

Conditions we will control:

Stop DNA Breakage -- Broken DNA improperly codes for functions in your body resulting in poor health and aging
Prevent Protein Unfolding -- Proteins can take the form of elegant molecules in the body that compose the body, as well as manage its functions. They can be extremely complex, and are formed in with folds in specific ways. Often they become unfolded, so they cannot do their jobs properly. We want to find ways to keep them in their correct shape and functioning properly.
Prevent cells from aging, and prevent faulty replication -- Activation of the cell repair process will be accomplished primarily through adult stem cells. AIF favors the use of adult stem cells. Although stem cell research is being conducted in a great many labs thruout the world, AIF will monitor this and fund development work in areas being overlooked, with emphasis on providing software systems to facilitate information sharing and collaboration among researchers
Prevent and Cure Diseases Caused By Specific Genes
Prevent Telomere Shortening -- Telomeres are the ends of DNA sections that shorten each time the cell replicates. When the telomere length falls below a certain threshold the cell no longer can divide
Preserve and repair mitochondria
Enable lysosomes (cell components) to eliminate harmful substances that accumulate with age
Remove harmful amyloid from the brain, as well as pancreas, heart and other organs
Control Oxidative Stress (free radical damage) Oxidative stress is caused by highly reactive molecules (“free radicals”) that are created in the energy factories within cells that go on to wreak havoc and damage cells and organs. It is involved in many diseases, such as atherosclerosis, Parkinson's disease and Alzheimer's disease. Therapeutics to mimic the positive effects of restricting caloric intake, among others, can help prevent these conditions
Prevent and Reverse the Glycation of Molecules in the Body Prevent proteins and other molecules from “crosslinking”, or sticking together and no longer work properly
Stimulate The Reversal Of Cholesterol Transport -- Pick up cholesterol from arteries and dispose of it
Repair and Restore Vascular Endothelial Function -- Restore clogged and damaged vessels
Stimulate Heat Shock Proteins -- Heat shock proteins are a class of proteins that protect other proteins and prevent them from unfolding under conditions of stress, such as heat
Reverse the wear and tear that accumulates over time

Some methods to accomplish the above:

Conventional pharmaceuticals
Stem Cell Therapies   -- Stem cells differentiate into a wide range of specialized cell types will be used to repair damaged tissues. Recent evidence that certain cells from adults may hold much of the curative potential previously believed unique to embryonic stem cells
Genetic engineering -- Modifying and enhancing DNA
Drugs that mimic caloric restriction -- So far restricting caloric intake is the only method shown to increase lifespan in animals. A calorimemetic would mimic this effect without restricting the diet
Nutraceuticals -- Foods with medicinal properties
Eventually, advanced methods like nanotechnology and artificial intelligence  -- “Nanobots” are tiny molecular machines that will repair cells and DNA, and artificial intelligence is the use of computers that mimic the thought processes of humans to solve complex biological (and other) problems

How We’ll Do This

     We’ll accomplish these goals by creating strategic partnerships with world class organizations. The AIF will provide the vision, clearly defined project plan and goals, specific technical expertise and money. All teams will be racing together toward the common goal of greatly extending and improving our lifespan, and the quality of our lives.

     Some representative organizations we will partner with (note: all organizations will pass through a comprehensive due diligence process): Go to partner organizations

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