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A
GING
I
NTERVENTION
F
OUNDATION
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Conditions we will control:
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Stop DNA Breakage -- Broken DNA improperly codes for functions
in your body resulting in poor health and aging |
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Prevent Protein Unfolding -- Proteins can take the form of elegant
molecules in the body that compose the body, as well as manage its functions. They
can be extremely complex, and are formed in with folds in specific ways. Often they
become unfolded, so they cannot do their jobs properly. We want to find ways to
keep them in their correct shape and functioning properly. |
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Prevent cells from aging, and prevent faulty replication -- Activation
of the cell repair process will be accomplished primarily through adult stem cells.
AIF favors the use of adult stem cells. Although stem cell research is being conducted
in a great many labs thruout the world, AIF will monitor this and fund development
work in areas being overlooked, with emphasis on providing software systems to facilitate
information sharing and collaboration among researchers |
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Prevent and Cure Diseases Caused By Specific Genes |
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Prevent Telomere Shortening -- Telomeres are the ends of DNA sections
that shorten each time the cell replicates. When the telomere length falls below
a certain threshold the cell no longer can divide |
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Preserve and repair mitochondria |
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Enable lysosomes (cell components) to eliminate harmful substances that accumulate
with age |
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Remove harmful amyloid from the brain, as well as pancreas,
heart and other organs |
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Control Oxidative Stress (free radical damage) Oxidative
stress is caused by highly reactive molecules (“free radicals”) that are created
in the energy factories within cells that go on to wreak havoc and damage cells
and organs. It is involved in many diseases, such as atherosclerosis, Parkinson's
disease and Alzheimer's disease. Therapeutics to mimic the positive effects of restricting
caloric intake, among others, can help prevent these conditions |
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Prevent and Reverse
the Glycation of Molecules in the Body Prevent proteins and other molecules from
“crosslinking”, or sticking together and no longer work properly |
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Stimulate The
Reversal Of Cholesterol Transport -- Pick up cholesterol from arteries and dispose
of it |
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Repair and Restore Vascular Endothelial Function -- Restore clogged and damaged vessels |
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Stimulate Heat Shock Proteins -- Heat shock proteins are a class of proteins
that protect other proteins and prevent them from unfolding under conditions of
stress, such as heat |
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Reverse the wear and tear that accumulates over time |
Some methods to accomplish the above:
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Conventional pharmaceuticals |
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Stem Cell Therapies -- Stem cells differentiate into a wide
range of specialized cell types will be used to repair damaged tissues. Recent evidence
that certain cells from adults may hold much of the curative potential previously
believed unique to embryonic stem cells |
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Genetic engineering -- Modifying and enhancing DNA |
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Drugs that mimic caloric restriction -- So far restricting caloric
intake is the only method shown to increase lifespan in animals. A calorimemetic
would mimic this effect without restricting the diet
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Nutraceuticals -- Foods with medicinal properties
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Eventually, advanced methods like nanotechnology and artificial intelligence
-- “Nanobots” are tiny molecular machines that will repair cells and DNA, and artificial
intelligence is the use of computers that mimic the thought processes of humans
to solve complex biological (and other) problems
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How We’ll Do This
We’ll accomplish these goals by creating strategic
partnerships with world class organizations. The AIF will provide the vision, clearly
defined project plan and goals, specific technical expertise and money. All teams
will be racing together toward the common goal of greatly extending and improving
our lifespan, and the quality of our lives.
Some representative organizations we
will partner with (note: all organizations will pass through a comprehensive due
diligence process): Go to partner organizations
If you are interested in supporting the foundation or
would like more information, click here to contact us
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