A GING   I NTERVENTION
F OUNDATION

		Oxidation, glycation, cross-linking, and other chemical modifications acting to impair the molecular functioning of multiple vital components in the body. Those affected include DNA, membranes, the extracellular matrix (ECM), enzymes, and structural proteins
		Debris and disorganization – both intracellular (inside the cell) and extracellular (outside the cell)
		Alteration in chemical equilibrium of cells (change in redox potential poise) -- results in a decreased ability to manage highly reactive and damaging molecules. This causes alterations in gene expression, enzyme activity, and signaling pathways Cell atrophy and loss
		Cell atrophy and loss
		Nuclear mutations – in nucleus, including DNA
		Decrease in repair and recycling effectiveness
		Mutant mitochondria (mitochondria are the “energy factories” within the cells that also control cellular processes)
		Harmful cells that are resistant to death -- visceral fat cells, supernumerary cells (toxic cells that accumulate in the cartilage in our joints and elsewhere) and dysfunctional immune cells)

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